Lipophilicity of opioids determined by a novel micromethod
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چکیده
منابع مشابه
Lipophilicity of opioids determined by a novel micromethod.
The lipophilicity of various mu-selective opioids was determined by measuring their distribution between n-octanol and Tris.HCl buffer, pH 7.4, by a procedure requiring submicromolar concentrations (submilligram amounts) of the compounds. After partitioning at 25 degrees C, the concentrations of opioids in the aqueous phase was quantified by their displacement of bound [3H]Tyr-Ala-Gly-(Me)Phe-G...
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In this study, the existence of biological potential of selected N-(substituted phenyl)-2-chloroacetamides was examined none empirically, as was the possibility of applying simpleexperimental technique in predicting essential properties which affect the biological activityof the compounds. By applying the Lipinski and Ghose’s rules, it has been revealed that theexamined chloroacetamides fulfill...
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ژورنال
عنوان ژورنال: Journal of Pharmacological and Toxicological Methods
سال: 1992
ISSN: 1056-8719
DOI: 10.1016/1056-8719(92)90023-t